De Vrij is back in the center of the defense, and he'll pair up with Skriniar while D'Ambrosio and Asamoah are expected to start on the sides of the defense. Brozovic and Vecino should play at midfield while the three upfront should be Politano, Nainggolan and Perisic. Icardi is favourite over Lautaro Martinez to get the striker place.
Inter (4-2-3-1): Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Brozovic, Vecino; Politano, Nainggolan, Perisic; Icardi.
Andreazzoli will have to do without Krunic, replaced by Afriyie Acquah, who's scored against Torino during the last game. Empoli will play with a 3-5-2 at San Siro, with an offensive duo composed of Caputo and Diego Farias while Maietta should be confirmed in defense.
Empoli (3-5-2): Dragowski; Maietta, Silvestre, Dell'Orco; Di Lorenzo, Traoré, Bennacer, Acquah, Pajac; Caputo, Farias.
